AUTHOR=Klein Ines , Boenert Janne , Lange Felix , Christensen Britt , Wassermann Meike K. , Wiesen Martin H. J. , Olschewski Daniel Navin , Rabenstein Monika , Müller Carsten , Lehmann Helmar C. , Fink Gereon Rudolf , Schroeter Michael , Rueger Maria Adele , Vay Sabine Ulrike TITLE=Glia from the central and peripheral nervous system are differentially affected by paclitaxel chemotherapy via modulating their neuroinflammatory and neuroregenerative properties JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1038285 DOI=10.3389/fphar.2022.1038285 ISSN=1663-9812 ABSTRACT=
Glia are critical players in defining synaptic contacts and maintaining neuronal homeostasis. Both astrocytes as glia of the central nervous system (CNS), as well as satellite glial cells (SGC) as glia of the peripheral nervous system (PNS), intimately interact with microglia, especially under pathological conditions when glia regulate degenerative as well as regenerative processes. The chemotherapeutic agent paclitaxel evokes peripheral neuropathy and cognitive deficits; however, the mechanisms underlying these diverse clinical side effects are unclear. We aimed to elucidate the direct effects of paclitaxel on the function of astrocytes, microglia, and SGCs, and their glia-glia and neuronal-glia interactions. After intravenous application, paclitaxel was present in the dorsal root ganglia of the PNS and the CNS of rodents.