AUTHOR=Gao Song , Jiang Xingyue , Wang Liang , Jiang Shanshan , Luo Hanyuan , Chen Yan , Peng Cheng 

TITLE=The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1029601

DOI=10.3389/fphar.2022.1029601

ISSN=1663-9812

ABSTRACT=<p>Liver cancer is the third most common cause of cancer-related deaths in the world and has become an urgent problem for global public health. Bioactive substances are widely used for the treatment of liver cancer due to their widespread availability and reduced side effects. This review summarizes the main pathogenic factors involved in the development of liver cancer, including metabolic fatty liver disease, viral infection, and alcoholic cirrhosis, and focuses on the mechanism of action of bioactive components such as polysaccharides, alkaloids, phenols, peptides, and active bacteria/fungi. In addition, we also summarize transformation methods, combined therapy and modification of bioactive substances to improve the treatment efficiency against liver cancer, highlighting new ideas in this field.</p>