AUTHOR=Bhat Javeed Ahmad , Akther Tahira , Najar Rauf Ahmad , Rasool Faheem , Hamid Abid 

TITLE=Withania somnifera (L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1029123

DOI=10.3389/fphar.2022.1029123

ISSN=1663-9812

ABSTRACT=<p>Cancer and Neurodegenerative diseases are one of the most dreadful diseases to cure and chemotherapy has found a prime place in cancerous treatments while as different strategies have been tested in neurodegenerative diseases as well. However, due to adverse shortcomings like the resistance of cancerous cells and inefficiency in neurodegenerative disease, plant sources have always found a prime importance in medicinal use for decades, <italic>Withania somnifera</italic> (L.) Dunal (<italic>W</italic>. <italic>somnifera</italic>) is a well-known plant with medicinal use reported for centuries. It is commonly known as winter cherry or ashwagandha and is a prime source of pharmaceutically active compounds withanolides. In recent years research is being carried in understanding the extensive role of <italic>W</italic>. <italic>somnifera</italic> in cancer and neurological disorders. <italic>W</italic>. <italic>somnifera</italic> has been reported to be beneficial in DNA repair mechanisms; it is known for its cellular repairing properties and helps to prevent the apoptosis of normal cells. This review summarizes the potential properties and medicinal benefits of <italic>W</italic>. <italic>somnifera</italic> especially in cancer and neurodegenerative diseases. Available data suggest that <italic>W</italic>. <italic>somnifera</italic> is effective in controlling disease progressions and could be a potential therapeutic target benefiting human health status. The current review also discusses the traditional medicinal applications of <italic>W</italic>. <italic>somnifera</italic>, the experimental evidence supporting its therapeutical potential as well as obstacles that necessitate being overcome for <italic>W</italic>. <italic>somnifera</italic> to be evaluated as a curative agent in humans.</p>