AUTHOR=Li Yan , Li Lingyu , Li Xiaoyun , Luo Bingjie , Ye Qianyun , Wang Haoyu , Yang Li , Zhu Xiaofeng , Han Li , Zhang Ronghua , Tian Huaqin , Wang Panpan 

TITLE=A mechanistic review of chinese medicine polyphenols on bone formation and resorption

JOURNAL=Frontiers in Pharmacology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1017538

DOI=10.3389/fphar.2022.1017538

ISSN=1663-9812

ABSTRACT=<p>Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts. If this balance is broken, it will lead to bone mass loss, bone density reduction, and bone metabolic diseases, such as osteoporosis. Polyphenols in Chinese herbal medicines are active ingredients in plant extracts with high safety and few side effects, and they can play a role in affecting bone formation and bone resorption. Some of these have estrogen-like effects and can better target bone health in postmenopausal women. The purpose of this review is to provide comprehensive information on the mechanisms underlying the relationship between traditional Chinese medicine polyphenols and bone formation or bone resorption.</p>