AUTHOR=Li Qirong , Wang Dongxu , Ding Dayong , Feng Ye , Hou Ruizhi , Liu Dianfeng , Lin Chao , Gao Yongjian 

TITLE=The Role and Application of Exosomes in Gastric and Colorectal Cancer

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.825475

DOI=10.3389/fphar.2021.825475

ISSN=1663-9812

ABSTRACT=<p>Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes—small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.</p>