AUTHOR=Li Huajie , Yu Zhenjie , Sun Haoyi , Liu Bo , Wang Xin , Shao Zhe , Wang Meiling , Xie Weilin , Yao Xingang , Yao Qingqiang , Zhi Ying 

TITLE=Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.821518

DOI=10.3389/fphar.2021.821518

ISSN=1663-9812

ABSTRACT=<p>A novel formal (4 + 1) annulation between <italic>N</italic>-(<italic>o</italic>-chloromethyl)aryl amides and 3-chlorooxindoles through <italic>in situ</italic> generated aza-<italic>ortho</italic>-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured illumination microscopy, compound <bold>3a</bold> is found to change the mitochondrial morphology and induce mitophagy pathway, which might then trigger mitophagy in cancer cells.</p>