AUTHOR=Xia Dan , Zhang Xinyang , Deng Di , Ma Xiaoyan , Masri Samer , Wang Jianzheng , Bao Shaowen , Hu Songnian , Zhou Qiang TITLE=Long-Term Enhancement of NMDA Receptor Function in Inhibitory Neurons Preferentially Modulates Potassium Channels and Cell Adhesion Molecules JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.796179 DOI=10.3389/fphar.2021.796179 ISSN=1663-9812 ABSTRACT=
Effectively enhancing the activity of inhibitory neurons has great therapeutic potentials since their reduced function/activity has significant contributions to pathology in various brain diseases. We showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity