AUTHOR=Bai Yi-ling , Han Ling-ling , Qian Jun-hui , Wang Hao-zhong 

TITLE=Molecular Mechanism of Puerarin Against Diabetes and its Complications

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.780419

DOI=10.3389/fphar.2021.780419

ISSN=1663-9812

ABSTRACT=<p><italic>Puerarin</italic> is a predominant component of <italic>Radix Puerarin</italic>. Despite its anti-tumor and anti-virus effects and efficacy in improving cardiovascular or cerebrovascular diseases and preventing osteoporosis, it has been shown to protect against diabetes and its complications. This review summarizes the current knowledge on <italic>Puerarin</italic> in diabetes and related complications, aiming to provide an overview of antidiabetic mechanisms of <italic>Puerarin</italic> and new targets for treatment.</p>