AUTHOR=Sosnovtseva Anastasiia O. , Stepanova Olga V. , Stepanenko Aleksei A. , Voronova Anastasia D. , Chadin Andrey V. , Valikhov Marat P. , Chekhonin Vladimir P. 

TITLE=Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.777628

DOI=10.3389/fphar.2021.777628

ISSN=1663-9812

ABSTRACT=<p>The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy is a popular approach for the treatment of such patients. The delivery of therapeutic genes is carried out in a variety of ways, such as direct injection of therapeutic vectors at the site of injury, retrograde delivery of vectors, and <italic>ex vivo</italic> therapy using various cells. Recombinant adenoviruses are often used as vectors for gene transfer. This review discusses the advantages, limitations and prospects of adenovectors in spinal cord injury therapy.</p>