AUTHOR=Shao Minghai , Ye Chaoyang , Bayliss George , Zhuang Shougang 

TITLE=New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.774414

DOI=10.3389/fphar.2021.774414

ISSN=1663-9812

ABSTRACT=<p>The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: <italic>Abelmoschus manihot</italic> and <italic>Huangkui capsule</italic>, <italic>Salvia miltiorrhiza</italic> and its components (tanshinone II A, salvianolic acid A and B); <italic>Rhizoma coptidis</italic> and its monomer <italic>berberine</italic>; <italic>Tripterygium wilfordii</italic> and its components (triptolide, tripterygium glycosides); Kudzu root <italic>Pueraria</italic> and its monomer <italic>Puerarin</italic>. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.</p>