AUTHOR=Nortey Jeremy , Smith David , Seitzman Gerami D. , Gonzales John A. 

TITLE=Topical Therapeutic Options in Corneal Neuropathic Pain

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.769909

DOI=10.3389/fphar.2021.769909

ISSN=1663-9812

ABSTRACT=<p><bold>Purpose of Review:</bold> Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies.</p><p><bold>Recent Findings:</bold> Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered.</p><p><bold>Summary:</bold> Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.</p>