AUTHOR=Peng Xiaoyuan , Ma Yiyang , Wang Qiyang , Gao Yanchun , Li Guangyi , Jiang Chenyi , Gao Yun , Feng Yong 

TITLE=Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.767243

DOI=10.3389/fphar.2021.767243

ISSN=1663-9812

ABSTRACT=<p>Osteonecrosis of femoral head (ONFH) is a progressive hip joint disease without disease-modifying treatment. Lacking understanding of the pathophysiological process of ONFH has become the humper to develop therapeutic approach. Serum amyloid A (SAA) is an acute phase lipophilic protein during inflammation and we found that SAA is increased for the first time in the serum of ONFH patients through proteomic studies and quantitatively verified by ELISA. Treating rBMSCs with SAA inhibited the osteogenic differentiation <italic>via</italic> Wnt/β-catenin signaling pathway deactivation and enhanced the adipogenic differentiation <italic>via</italic> MAPK/PPARγ signaling pathway activation. Finally, bilateral critical-sized calvarial-defect rat model which received SAA treated rBMSCs demonstrated reduction of bone formation when compared to untreated rBMSCs implantation control. Hence, SAA is a vital protein in the physiological process of ONFH and can act as a potential therapeutic target to treat ONFH.</p>