AUTHOR=Wang Yonghui , Hou Meihui , Kan Zhaodong , Zhang Guanghui , Li Yunxia , Zhou Lei , Wang Changfa 

TITLE=Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.764191

DOI=10.3389/fphar.2021.764191

ISSN=1663-9812

ABSTRACT=<p>Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of <italic>Salmonella</italic> species strains including <italic>S. enteritidis</italic>, <italic>S. typhi</italic>, <italic>S. typhimurium</italic>, <italic>S. paratyphi</italic>, and <italic>S. abortus equi</italic>, and their minimum inhibitory concentrations ranged from 1 to 53 μg/ml. Especially, these compounds showed comparable activity as the of the positive control gatifloxacin towards <italic>S. abortus equi</italic>. The present results suggest that these new T3SS inhibitors could be used as a potential lead molecule for drug development of anti-<italic>Salmonella</italic>.</p>