AUTHOR=Li Xiangyu , Liu Ming , Zhao Junfeng , Ren Tong , Yan Xin , Zhang Lijun , Wang Xun 

TITLE=Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.750857

DOI=10.3389/fphar.2021.750857

ISSN=1663-9812

ABSTRACT=<p>Gliomas are the most common primary tumors of the central nervous system. Due to the existence of the blood-brain barrier and its unique regional immune characteristics, the study of the immune microenvironment of gliomas is particularly important. Glioma stem cells are an important cause of initiating glioma, promoting tumor progression and leading to tumor recurrence. Immunotherapeutic strategies targeting glioma stem cells have become the focus of current research. This paper will focus on the research progress of glioma stem cells in the immune microenvironment of glioma to provide the basis for the immunotherapy of glioma.</p>