AUTHOR=Rong Yumei , Hong Ge , Zhu Na , Liu Yang , Jiang Yong , Liu Tianjun 

TITLE=Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis via Inhibition of AOC1

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.746725

DOI=10.3389/fphar.2021.746725

ISSN=1663-9812

ABSTRACT=<p>Ulcerative colitis (UC), a chronic, nonspecific inflammatory bowel disease characterized by continuous and diffuse inflammatory changes in the colonic mucosa, requires novel treatment method. Photodynamic therapy (PDT), as a promising physico-chemical treatment method, were used to treat UC rats’ model with novel photosensitizer LD<sub>4</sub> in this paper, the treatment effect and mechanism was investigated. LD<sub>4</sub>-PDT could improve the survival rate of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced UC model rats, decrease expression of interleukin (IL)-6, IL-1, tumor necrosis factor (TNF)-<italic>α</italic>, malondialdehyde (MDA), myeloperoxidase (MPO) and increase the expression of glutathione (GSH) and superoxide oxidase (SOD), while protecting the integrity of the intestinal epithelium. LD<sub>4</sub>-PDT treatment could rebuild the intestinal microflora composition and reprogram the colonic protein profiles in TNBS-induced rats to almost the normal state. Proteomics analysis based upon TNBS-induced UC model rats revealed that Amine oxidase copper-containing 1 (AOC<sub>1</sub>) was a potential target of LD<sub>4</sub>-PDT. Novel photosensitizer agent LD<sub>4</sub>-PDT represents an efficient treatment method for UC, and AOC<sub>1</sub> may be a promising target.</p>