AUTHOR=Kerckhove Nicolas , Selvy Marie , Lambert Céline , Gonneau Coralie , Feydel Gabrielle , Pétorin Caroline , Vimal-Baguet Agnès , Melnikov Sergey , Kullab Sharif , Hebbar Mohamed , Bouché Olivier , Slimano Florian , Bourgeois Vincent , Lebrun-Ly Valérie , Thuillier Frédéric , Mazard Thibault , Tavan David , Benmammar Kheir Eddine , Monange Brigitte , Ramdani Mohamed , Péré-Vergé Denis , Huet-Penz Floriane , Bedjaoui Ahmed , Genty Florent , Leyronnas Cécile , Busserolles Jérôme , Trévis Sophie , Pinon Vincent , Pezet Denis , Balayssac David TITLE=Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.744085 DOI=10.3389/fphar.2021.744085 ISSN=1663-9812 ABSTRACT=

Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients’ characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management.