AUTHOR=Maioli Tatiani Uceli , Borras-Nogues Esther , Torres Licia , Barbosa Sara Candida , Martins Vinicius Dantas , Langella Philippe , Azevedo Vasco Ariston , Chatel Jean-Marc TITLE=Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.740636 DOI=10.3389/fphar.2021.740636 ISSN=1663-9812 ABSTRACT=

Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, which contributes to chronic inflammation in the gut and adipose tissues, and to the development of insulin resistance. In this review, we examine the interplay between gut inflammation, insulin resistance, and the gut microbiota, and discuss how some probiotic species can be used to modulate gut homeostasis. We focus primarily on Faecalibacterium prausnitzii, a highly abundant butyrate-producing bacterium that has been proposed both as a biomarker for the development of different gut pathologies and as a potential treatment due to its production of anti-inflammatory metabolites.