AUTHOR=Skroza Nevena , Tolino Ersilia , Balduzzi Veronica , Bernardini Nicoletta , Mambrin Alessandra , Marchesiello Anna , Marraffa Federica , Rossi Giovanni , Volpe Salvatore , Proietti Ilaria , Potenza Concetta 

TITLE=Advantages of Tailored Isotretinoin Treatment in Moderate to Severe Acne: Real-Life Data

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.733526

DOI=10.3389/fphar.2021.733526

ISSN=1663-9812

ABSTRACT=<p>This retrospective single-center study analyzes the efficacy and safety of isotretinoin for the treatment of moderate to severe acne in real-life clinical practice, particularly with regard to acne severity, isotretinoin cumulative dosage, and patients’ gender. The results suggest the opportunity of an early isotretinoin systemic treatment in patients affected by moderate acne and emphasize the importance of an appropriate dose adjustment in order to minimize adverse events.</p>