AUTHOR=Rezaei Shahla , Tabrizi Reza , Nowrouzi-Sohrabi Peyman , Jalali Mohammad , Shabani-Borujeni Mojtaba , Modaresi Shayan , Gholamalizadeh Maryam , Doaei Saeid 

TITLE=The Effects of Vitamin D Supplementation on Anthropometric and Biochemical Indices in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.732496

DOI=10.3389/fphar.2021.732496

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> Vitamin D was reported to be associated with non−alcoholic fatty liver disease (NAFLD). This systematic review and meta−analysis aimed to investigate the effects of the vitamin D supplementation on anthropometric and biochemical indices in patient with NAFLD.</p><p><bold>Methods:</bold> PubMed, Web of science, Scopus, and Embase databases were explored to identify all randomized controlled trial (RCT) investigating the effects of vitamin D supplementation on anthropometric and biochemical indices in patients with NAFLD. A random−effects model was used to pool weighted mean difference (WMD) and corresponding 95% confidence intervals (CIs). The statistical heterogeneity among the studies was assessed using I2 statistic (high ≥ 50%, low &lt; 50%) and Cochran’s Q−test.</p><p><bold>Results:</bold> Sixteen RCTs were included in this meta−analysis. The results identified that high−density lipoprotein−cholesterol (HDL−C) level significantly increased following vitamin D supplementation (<italic>P</italic> = 0.008). Vitamin D reduced body weight (<italic>P</italic> = 0.007), body mass index (<italic>P</italic> = 0.002), waist circumstance (WC) (<italic>P</italic> = 0.02), serum alanine transaminase (ALT) (<italic>P</italic> = 0.01), fasting blood sugar (FBS) (<italic>P</italic> = 0.01), homeostatic model assessment for insulin resistance (HOMA−IR) (<italic>P</italic> = 0.004), and calcium (<italic>P</italic> = 0.01). No significant changes were found on body fat, triglyceride (TG), total cholesterol, low−density lipoprotein−cholesterol (LDL−C), aspartate transaminase, alkaline phosphatase, gamma−glutamyl transferase, and adiponectin following vitamin D supplementation.</p><p><bold>Conclusion:</bold> Vitamin D had significant effects on anthropometric and biochemical indices including HDL−C, body weight, BMI, WC, serum ALT, serum FBS, HOMA−IR, and calcium. Vitamin D supplementation can be considered as an effective strategy in management of patients with NAFLD.</p><p><bold>Systematic Review Registration</bold>: [website], identifier [registration number]</p>