AUTHOR=Hu Jianming , Zhang Leyi , Chen Wuzhen , Shen Lesang , Jiang Jingxin , Sun Shanshan , Chen Zhigang 

TITLE=Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.730751

DOI=10.3389/fphar.2021.730751

ISSN=1663-9812

ABSTRACT=<p>Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal factors through flexible metabolic reprogramming. Abnormal lipid metabolism has been reported to be involved in the cancer stemness and promote the development of cancer. Lipid metabolism includes lipid uptake, lipolysis, fatty acid oxidation, <italic>de novo</italic> lipogenesis, and lipid desaturation. Abnormal lipid metabolism leads to ferroptosis of CSCs. In this review, we comprehensively summarized the role of intra- and extracellular lipid signals in cancer stemness, and explored the feasibility of using lipid metabolism-related treatment strategies for future cancer.</p>