AUTHOR=Hou Xiaoying , Zhang Pei , Du Hongzhi , Chu Weihua , Sun Ruiqi , Qin Siyuan , Tian Yuan , Zhang Zunjian , Xu Fengguo TITLE=Akkermansia Muciniphila Potentiates the Antitumor Efficacy of FOLFOX in Colon Cancer JOURNAL=Frontiers in Pharmacology VOLUME=Volume 12 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.725583 DOI=10.3389/fphar.2021.725583 ISSN=1663-9812 ABSTRACT=
FOLFOX (oxaliplatin, fluorouracil and calcium folinate) is the first-line chemotherapy regimen for colon cancer therapy in the clinic. It provides superior efficacy than oxaliplatin alone, but the underlying mechanism remains unclear. In the present study, pharmacomicrobiomics integrated with metabolomics was conducted to uncover the role of the gut microbiome behind this. First,