AUTHOR=Verbeure Wout , van Goor Harry , Mori Hideki , van Beek André P. , Tack Jan , van Dijk Peter R. 

TITLE=The Role of Gasotransmitters in Gut Peptide Actions

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.720703

DOI=10.3389/fphar.2021.720703

ISSN=1663-9812

ABSTRACT=<p>Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H<sub>2</sub>S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles relaxations, anti-inflammatory behavior, protective effect and more. Many of these physiological processes are upstream regulated by gut peptides, for instance gastrin, cholecystokinin, secretin, motilin, ghrelin, glucagon-like peptide 1 and 2. The relationship between gasotransmitters and gut hormones is poorly understood. In this review, we discuss the role of NO, CO and H<sub>2</sub>S on gut peptide release and functioning, and whether manipulation by gasotransmitter substrates or specific blockers leads to physiological alterations.</p>