AUTHOR=Chen Bangjie , Rao Xianyue , Wang Xinyi , Luo Zhipan , Wang Jianpeng , Sheng Shuyan , Liu Yuchen , Zhang Ning , Jin Shiyu , Chen Haosong , Sun Chenyu , Xu Tao , Du Yingying TITLE=cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical Practice JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.719644 DOI=10.3389/fphar.2021.719644 ISSN=1663-9812 ABSTRACT=

The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely related to the progress of liver diseases. For example, activating the cGAS-STING signaling pathway could significantly inhibit hepatitis B virus (HBV) replication in vivo. Moreover, the cGAS-STING signaling pathway was also closely associated with tumor immunity in hepatocellular carcinoma (HCC). This review summarized the role of the cGAS-STING signaling pathway in several common liver diseases, especially the current application of the cGAS-STING signaling pathway in liver disease treatment, and prospected its future research, which provided a new idea for understanding and treating liver diseases.