AUTHOR=Yang Fuxun , Zeng Fan , Luo Xiaoxiu , Lei Yu , Li Jiajia , Lu Sen , Huang Xiaobo , Lan Yunping , Liu Rongan TITLE=GLP-1 Receptor: A New Target for Sepsis JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.706908 DOI=10.3389/fphar.2021.706908 ISSN=1663-9812 ABSTRACT=

Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.