AUTHOR=Li Shuangfeng , Wang Ying , Chen Xiaojian , Huang Tingwan , Li Na TITLE=Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.673550 DOI=10.3389/fphar.2021.673550 ISSN=1663-9812 ABSTRACT=

Objective: This prospective study evaluated the 50% effective dose (ED₅₀) and 95% effective dose (ED₉₅) of nalbuphine combined with propofol during painless gastroscopy.

Methods: Seventy-five patients who underwent painless gastroscopy were randomly divided into five groups (group N₀, N_0.05, N_0.1, N_0.15, and N_0.2), with doses of 0, 0.05, 0.1, 0.15, or 0.2 mg/kg nalbuphine in each group. Propofol was given to all groups as the sedative. The bispectral index (BIS) value, propofol dose, examination time, and awakening time were recorded. The number of patients with intolerance indexes (coughing, retching, swallowing, or limb movement) was recorded in each group. The ED₅₀/ED₉₅ of nalbuphine combined with propofol for gastroscopy were calculated.

Results: Compared with those of groups N₀, N_0.05, or N_0.1, the propofol dose and awakening time were significantly reduced in group N_0.15 or N_0.2 (p < 0.05). The successful rate of painless gastroscopy in group N_0.15 or N_0.2 significantly increased compared to that of group N₀ or N_0.05 (p < 0.05). When combined with propofol, nalbuphine had an ED₅₀ and ED₉₅ for painless gastroscopy of 0.078 mg/kg (95% CI, 0.056–0.098 mg/kg) and 0.162 mg/kg (95% CI, 0.134–0.217 mg/kg), respectively.

Conclusion: The ED₅₀/ED₉₅ of nalbuphine combined with propofol are 0.078 and 0.162 mg/kg, respectively, for painless gastroscopy. Nalbuphine at 0.162 mg/kg combined with propofol is effective and safe for painless gastroscopy in adults.