AUTHOR=Costa Rafael Fernades , Turones Larissa Córdova , Cavalcante Keilah Valéria Naves , Rosa Júnior Ismael Aureliano , Xavier Carlos Henrique , Rosseto Lucimar Pinheiro , Napolitano Hamilton Barbosa , Castro Patrícia Ferreira da Silva , Neto Marcos Luiz Ferreira , Galvão Gustavo Mota , Menegatti Ricardo , Pedrino Gustavo Rodrigues , Costa Elson Alves , Martins José Luis Rodrigues , Fajemiroye James Oluwagbamigbe TITLE=Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.666725 DOI=10.3389/fphar.2021.666725 ISSN=1663-9812 ABSTRACT=

Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs. Numerous interactions of these derivatives at their targets could impact future research considerations and prospects while offering opportunities for optimizing therapeutic activity with fewer adverse effects.