AUTHOR=Yang Bo , Zhao Fang , Yao Lei , Zong Zhenfeng , Xiao Li 

TITLE=CircRNA circ_0006677 Inhibits the Progression and Glycolysis in Non–Small-Cell Lung Cancer by Sponging miR-578 and Regulating SOCS2 Expression

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.657053

DOI=10.3389/fphar.2021.657053

ISSN=1663-9812

ABSTRACT=<p><bold>Objective:</bold> Circular RNAs (circRNAs) have been demonstrated in playing an important role in the physiological and pathological processes (such as cancer). This paper aims to clarify the role of Circ_0006677 in non–small-cell lung cancer (NSCLC) progression.</p><p><bold>Methods:</bold> Using clinical data and <italic>in vitro</italic> cell line models, we revealed the tumor-suppressive role of circ_0006677 in lung cancer. Using the online bioinformatics tool, we predicted the target of circ_0006677 and further validated its regulatory mechanisms responsible for its tumor suppressor function in NSCLC.</p><p><bold>Results:</bold> Circ_0006677 expression was reduced in NSCLC tissues of patients and lung cancer cells in comparison to adjacent normal tissues. Lower expression of circ_0006677 was significantly associated with poorer patient survival. Overexpression of circ_0006677 significantly inhibited the ability of NSCLC cell proliferation, migration, invasion, and glycolysis. Mechanically, circ_0006677 could inhibit NSCLC progression and glycolysis by regulating the expression of the signal transducer inhibitor SOSC2 through sponging microRNA-578 (miR-578).</p><p><bold>Conclusion:</bold> Circ_0006677 prevents the progression of NSCLC <italic>via</italic> modulating the miR-578/SOSC2 axis.</p>