AUTHOR=Caruso Vanni , Zuccarini Mariachiara , Di Iorio Patrizia , Muhammad Ishaq , Ronci Maurizio 

TITLE=Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.655989

DOI=10.3389/fphar.2021.655989

ISSN=1663-9812

ABSTRACT=<p>The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.</p>