AUTHOR=Tong Yuling , Liu Liping , Wang Ruilin , Yang Tao , Wen Jianxia , Wei Shizhang , Jing Manyi , Zou Wenjun , Zhao Yanling TITLE=Berberine Attenuates Chronic Atrophic Gastritis Induced by MNNG and Its Potential Mechanism JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.644638 DOI=10.3389/fphar.2021.644638 ISSN=1663-9812 ABSTRACT=
The purpose of this study was to investigate the therapeutic effect of berberine (BBR) on MNNG-induced chronic atrophic gastritis (CAG) and the possible mechanism of BBR through TGF-β1/PI3K signal pathway. GES-1 were pretreated with MNNG for 2 h before BBR treatment in all procedures. Cell viability was quantified by cell counting kit-8, and GES-1 morphology and proliferation were detected by high content screening (HCS) assay. The rat model of CAG was established by MNNG, and the therapeutic effect of BBR on stomach histopathology and serum supernatant were analyzed