AUTHOR=Liu Yanan , Wang Canwei , Li Jifa , Zhu Jiandong , Zhao Chengguang , Xu Huanhai 

TITLE=Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.633453

DOI=10.3389/fphar.2021.633453

ISSN=1663-9812

ABSTRACT=<p>Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.</p>