AUTHOR=Wang Zhicheng , Li Yumin , Zhang Tong , Li Hongxia , Yang Zhao , Wang Cheng 

TITLE=Effect of Micelle-Incorporated Cisplatin With Sizes Ranging From 8 to 40 nm for the Therapy of Lewis Lung Carcinoma

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.632877

DOI=10.3389/fphar.2021.632877

ISSN=1663-9812

ABSTRACT=<p>Insufficient transport of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Block copolymers are promising carriers with smaller particle size by ratio modification. Here, we constructed cisplatin nanoparticles with sizes ranging from 8 to 40 nm to study the permeability and therapy of Lewis lung carcinoma. We synthesized methoxypoly(ethylene glycol)<sub>2000</sub>-block poly(L-glutamic acid sodium salt)<sub>1979</sub> loading cisplatin through complexation reaction. The cisplatin nanomedicine has high drug loading and encapsulation efficiency. <italic>In vitro</italic> data demonstrated that cisplatin nanoparticles had equivalent growth-inhibiting effects on Lewis lung carcinoma cells compared to free cisplatin. <italic>In vivo</italic> evidences showed cisplatin nanoparticles had superior antitumor effects on the Lewis lung carcinoma mouse model with no obvious side effects. All results indicated that optimizing the ratio of block copolymers to obtain smaller sized nanomedicine could act as a promising strategy for overcoming the inadequate accumulation in poorly vascularized tumors.</p>