AUTHOR=Zhou Shiwei , Zeng Sujuan , Shu Yan 

TITLE=Drug-Drug Interactions at Organic Cation Transporter 1

JOURNAL=Frontiers in Pharmacology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.628705

DOI=10.3389/fphar.2021.628705

ISSN=1663-9812

ABSTRACT=<p>The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.</p>