This article is a correction to:
A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5
Zhi Xin1†
Cui Jin1†
Liu Chao2†Zhang Zheng1Cao Liehu3,4Pan Panpan3,4
Weng Weizong3,4Zhai Xiao3Zhao Qingjie2Hu Honggang2Qin Longjuan5
Chen Xiao3,4*
Su Jiacan3,4*- 1Graduate Management Unit, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
- 2School of Pharmacy, Second Military Medical University, Shanghai, China
- 3Department of Orthopedics, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
- 4China-South Korea Bioengineering Center, Shanghai, China
- 5Orthopedic Basic and Translational Research Center, Jiangyin, China
A Corrigendum on
A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss
by Targeting Ribosomal Protein S5 by Zhi, X., Cui, J., Liu, C., Zhang, Z., Cao, L., Pan, P., Weng, W., Zhai, X., Zhao, Q., Hu, H., Qin, L., Chen, X., and Su, J. (2018). Front. Pharmacol. 9:22. doi: 10.3389/fphar.2018.00022
In the original article, there were mistakes in Figures 1C, 6C as published. In Figure 1C, the original image of RANKL induced group was mistakenly selected. Figure 1C is now replaced with the right image. In Figure 6C, the original image of OVX group was wrongly selected.Figure 6C is now replaced with the right image. The corrected Figures 1C, 6C appear below.
FIGURE 1
FIGURE 1. M54 inhibits RANKL-induced osteoclast differentiation and bone resorption in vitro. (A) Chemical structure of M54 and the synthesis process. (B) Formation of TRAP-positive cells from BMMCs and the quantification of formed osteoclasts. (C) Formation of TRAP-positive cells from RAW264.7 cells and the quantification of formed osteoclasts. (D) The resorption area on the bone biomimetic synthetic surface was quantified by image analysis (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).
FIGURE 6
FIGURE 6. M54 prevents ovariectomy-induced bone loss in vivo. (A) Representative H&E staining of distal femoral sections and quantification of trabecular area from each group 6 week after the operation (×40). (B) Representative TRAP-stained histologic distal femur sections from sham, OVX and OVX + M54 group (×400). (C) Micro CT analysis of the distal femur from sham, OVX, and OVX + M54 group. (D) Calculations of bone value/total value (BV/TV), trabecular number (Tb.N), bone mineral density (BMD), and bone surface area/total value (BS/TV). (E) Serum TRAcp5B, TNF-α, and IL-6 were examined (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: RPS5, matrine derivative, RANKL, osteoclasts, AKT pathway
Citation: Xin Z, Jin C, Chao L, Zheng Z, Liehu C, Panpan P, Weizong W, Xiao Z, Qingjie Z, Honggang H, Longjuan Q, Xiao C and Jiacan S (2021) Corrigendum: A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5. Front. Pharmacol. 12:605592 correction. doi: 10.3389/fphar.2021.605592
Received: 15 September 2020; Accepted: 08 February 2021;
Published: 29 March 2021.
Edited by:
Patrizia Ballerini, University of Studies G. d’Annunzio Chieti and Pescara, ItalyReviewed by:
Satish Ramalingam, SRM Institute of Science and Technology, IndiaCopyright © 2021 Xin, Jin, Chao, Zheng, Liehu, Panpan, Weizong, Xiao, Qingjie, Honggang, Longjuan, Xiao and Jiacan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Chen Xiao, sirchenxiao@126.com; Su Jiacan, drsujiacan@163.com
†These authors have contributed equally to this work