AUTHOR=Fang Zhong‐ying , Zhang Miao , Liu Jia-ning , Zhao Xue , Zhang Yong-qing , Fang Lei 

TITLE=Tanshinone IIA: A Review of its Anticancer Effects

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.611087

DOI=10.3389/fphar.2020.611087

ISSN=1663-9812

ABSTRACT=<p>Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb <italic>Salvia miltiorrhiza</italic> Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with cardiovascular system, diabetes, apoplexy, arthritis, sepsis, and other diseases. Recently, it was reported that tan IIA could have a wide range of antitumor effects on several human tumor cell lines, but the research of the mechanism of tan IIA is relatively scattered in cancer. This review aimed to summarize the recent advances in the anticancer effects of tan IIA and to provide a novel perspective on clinical use of tan IIA.</p>