AUTHOR=Xiong Hua-Long , Cao Jia-Li , Shen Chen-Guang , Ma Jian , Qiao Xiao-Yang , Shi Tian-Shu , Ge Sheng-Xiang , Ye Hui-Ming , Zhang Jun , Yuan Quan , Zhang Tian-Ying , Xia Ning-Shao 

TITLE=Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.609592

DOI=10.3389/fphar.2020.609592

ISSN=1663-9812

ABSTRACT=<p>To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.</p>