AUTHOR=Chen Yewei , Sun Li , Xu Hong , Dong Min , Mizuno Tomoyuki , Vinks Alexander A. , Brunner Hermine I. , Li Yifan , Li Zhiping 

TITLE=PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.605060

DOI=10.3389/fphar.2020.605060

ISSN=1663-9812

ABSTRACT=<p><bold>Objectives:</bold> To evaluate the mycophenolic acid [MPA, the active form of mycophenolate mofetil (MMF)] pharmacokinetic parameters in relation to clinical response to identify target exposure ranges in pediatric patients with systemic lupus erythematosus (SLE).</p><p><bold>Methods:</bold> This was a retrospective study using pharmacokinetic data collected in 67 pediatric patients aged 4–18 years with SLE. Target MPA exposures for effective inhibition of SLE activity (as measured by SLE disease Activity Index (SLEDAI), active SLE was defined as a SLEDAI score of ≥6, and a controlled disease was defined as a SLEDAI score of ≤4) were assessed by receiver operating characteristic (ROC) curve and logistic regression. Exposure-response models were developed to quantitatively describe the relationship between SLEDAI score and AUC<sub>0–12</sub> or C<sub>trough</sub>, respectively.</p><p><bold>Results:</bold> The MPA AUC<sub>0-12</sub> in patients with active SLE was significantly lower than that in patients with inactive SLE. ROC analysis revealed that an AUC<sub>0–12</sub> threshold of 39 μg h/ml or a C<sub>trough</sub> of 1.01 μg/ml was associated with the lowest risk of active SLE. Logistic regression analysis revealed that an AUC<sub>0–12</sub> of less than 34 μg h/ml or a C<sub>trough</sub> of less than 1.2 μg/ml probably is associated with active SLE. The results of the exposure-response modeling also indicated that an AUC<sub>0-12</sub> less than 32 μg h/ml or a C<sub>trough</sub> less than 1.1 μg/ml was associated with suboptimal clinical outcome. An AUC<sub>0-12</sub> above 50 μg h/ml or a C<sub>trough</sub> above 1.7 ug/ml was associated with disease control.</p><p><bold>Conclusion:</bold> Both AUC<sub>0–12</sub> and C<sub>trough</sub> of MPA are predictive of the likelihood of active SLE in pediatric patients receiving MMF. An individualized dosing regimen of MMF, with a target AUC<sub>0–12</sub> or C<sub>trough</sub>, should be considered for SLE patients.</p>