AUTHOR=Kim Seonghun , Jeong Cheol-Hee , Song Sang Hyun , Um Jo Eun , Kim Hyun Sil , Yun Jun Seop , Han Dawool , Cho Eunae Sandra , Nam Bo Young , Yook Jong In , Ku Minhee , Yang Jaemoon , Kim Man-Deuk , Kim Nam Hee , Yoo Tae-Hyun TITLE=Micellized Protein Transduction Domain-Bone Morphogenetic Protein-7 Efficiently Blocks Renal Fibrosis Via Inhibition of Transforming Growth Factor-Beta–Mediated Epithelial–Mesenchymal Transition JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.591275 DOI=10.3389/fphar.2020.591275 ISSN=1663-9812 ABSTRACT=
Tubulointerstitial renal fibrosis is a chronic disease process affecting chronic kidney disease (CKD). While the etiological role of transforming growth factor-beta (TGF-β) is well known for epithelial–mesenchymal transition (EMT) in chronic kidney disease, effective therapeutics for renal fibrosis are largely limited. As a member of the TGF-β superfamily, bone morphogenetic protein-7 (BMP-7) plays an important role as an endogenous antagonist of TGF-β, inhibiting fibrotic progression in many organs. However, soluble rhBMP-7 is hardly available for therapeutics due to its limited pharmacodynamic profile and rapid clearance in clinical settings. In this study, we have developed a novel therapeutic approach with protein transduction domain (PTD) fused BMP-7 in micelle (mPTD-BMP-7) for long-range signaling