AUTHOR=Chen Rong , Tang Ling-hua , Sun Tao , Zeng Zi , Zhang Yun-yan , Ding Ke , Meng Qing-tao 

TITLE=Mechanism and Management of Fentanyl-Induced Cough

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.584177

DOI=10.3389/fphar.2020.584177

ISSN=1663-9812

ABSTRACT=<p>Fentanyl-induced cough (FIC) often occurs after intravenous bolus administration of fentanyl analogs during induction of general anesthesia and analgesia procedure. The cough is generally benign, but sometimes it causes undesirable side effects, including elevated intra-abdominal, intracranial or intraocular pressure. Therefore, understanding the related mechanisms and influencing factors are of great significance to prevent and treat the cough. This paper reviews the molecular mechanism, influencing factors and preventive administration of FIC, focusing on the efficacy and side effects of various drugs in inhibiting FIC to provide some medical reference for anesthesiologists.</p>