AUTHOR=Xin Laiyun , Gao Jialiang , Lin Hongchen , Qu Yi , Shang Chang , Wang Yuling , Lu Yingdong , Cui Xiangning 

TITLE=Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.583200

DOI=10.3389/fphar.2020.583200

ISSN=1663-9812

ABSTRACT=<p>Cardiovascular diseases (CVDs) is the leading cause of high morbidity and mortality worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In eastern countries, traditional Chinese medicine <italic>Scutellaria baicalensis</italic><italic>Georgi</italic> has been used clinically for thousands of years. Baicalin is one of the main active ingredients extracted from Chinese herbal medicine <italic>S. baicalensis</italic>. Emerging evidence has established that baicalin improves chronic inflammation, immune imbalance, disturbances in lipid metabolism, apoptosis and oxidative stress. Thereby it offers beneficial roles against the initiation and progression of CVDs such as atherosclerosis, hypertension, myocardial infarction and reperfusion, and heart failure. In this review, we summarize the pharmacological features and relevant mechanisms by which baicalin regulates CVDs in the hope to reveal its application for CVDs prevention and/or therapy.</p>