AUTHOR=van Schaik Ron H. N. , Müller Daniel J. , Serretti Alessandro , Ingelman-Sundberg Magnus 

TITLE=Pharmacogenetics in Psychiatry: An Update on Clinical Usability

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.575540

DOI=10.3389/fphar.2020.575540

ISSN=1663-9812

ABSTRACT=<p>Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics.</p>