AUTHOR=Osborne Vicki , Shakir Saad A. W. TITLE=What Is the Difference Between Observed Association and Causal Association, Signals and Evidence? Examples Related to COVID-19 JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.569189 DOI=10.3389/fphar.2020.569189 ISSN=1663-9812