AUTHOR=Hossain Md. Farhad , Hasana Sharifa , Mamun Abdullah Al , Uddin Md. Sahab , Wahed Mir Imam Ibne , Sarker Sabarni , Behl Tapan , Ullah Irfan , Begum Yesmin , Bulbul Israt Jahan , Amran Md. Shah , Rahman Md. Habibur , Bin-Jumah May N. , Alkahtani Saad , Mousa Shaker A. , Aleya Lotfi , Abdel-Daim Mohamed M. TITLE=COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.563478 DOI=10.3389/fphar.2020.563478 ISSN=1663-9812 ABSTRACT=

At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).