AUTHOR=Lillich Felix F. , Imig John D. , Proschak Ewgenij 

TITLE=Multi-Target Approaches in Metabolic Syndrome

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.554961

DOI=10.3389/fphar.2020.554961

ISSN=1663-9812

ABSTRACT=<p>Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires polypharmacological treatment of the single conditions including type II diabetes, hypertension, and dyslipidemia, as well as the associated comorbidities. The complex treatment regimens with various drugs lead to drug-drug interactions and inadequate patient adherence, resulting in poor management of the disease. Multi-target approaches aim at reducing the polypharmacology and improving the efficacy. This review summarizes the medicinal chemistry efforts to develop multi-target ligands for MetS. Different combinations of pharmacological targets in context of <italic>in vivo</italic> efficacy and future perspective for multi-target drugs in MetS are discussed.</p>