AUTHOR=Yahouédéhou Sètondji Cocou Modeste Alexandre , Neres Joelma Santana dos Santos , da Guarda Caroline Conceição , Carvalho Suellen Pinheiro , Santiago Rayra Pereira , Figueiredo Camylla Vilas Boas , Fiuza Luciana Magalhães , Ndidi Uche Samuel , de Oliveira Rodrigo Mota , Fonseca Cleverson Alves , Nascimento Valma Maria Lopes , Rocha Larissa Carneiro , Adanho Corynne Stéphanie Ahouéfa , da Rocha Tiago Santos Carvalho , Adorno Elisângela Vitória , Goncalves Marilda Souza TITLE=Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.553064 DOI=10.3389/fphar.2020.553064 ISSN=1663-9812 ABSTRACT=
Differences in hydroxyurea response in sickle cell anemia may arise due to a series of factors with genetic factors appearing to be predominant. This study aims to investigate the effects of single nucleotide polymorphisms in genes encoding drug-metabolizing enzymes and solute carriers on hydroxyurea response, in patients with sickle cell anemia. For that purpose, a total number of 90 patients with sickle cell anemia were recruited, 45 were undergoing hydroxyurea treatment, while 45 were not under the treatment. Association analyses were performed between