AUTHOR=Salehi Bahare , Sharifi-Rad Javad , Cappellini Francesca , Reiner Ċ½eljko , Zorzan Debora , Imran Muhammad , Sener Bilge , Kilic Mehtap , El-Shazly Mohamed , Fahmy Nouran M. , Al-Sayed Eman , Martorell Miquel , Tonelli Chiara , Petroni Katia , Docea Anca Oana , Calina Daniela , Maroyi Alfred TITLE=The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.01300 DOI=10.3389/fphar.2020.01300 ISSN=1663-9812 ABSTRACT=

Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.