AUTHOR=Na nakorn Chalitpon , Waisayarat Jariya , Dejthevaporn Charungthai , Srisawasdi Pornpen , Wongwaisayawan Sansanee , Sukasem Chonlaphat 

TITLE=Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00728

DOI=10.3389/fphar.2020.00728

ISSN=1663-9812

ABSTRACT=<sec><title>Aim</title><p>To investigate the variations and the frequencies of the <italic>SLCO1B1</italic> gene in the Thai population.</p></sec><sec><title>Methods</title><p>Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A&gt;G and c.521T&gt;C of the <italic>SLCO1B1,</italic> using TaqMan<sup>®</sup> real-time PCR.</p></sec><sec><title>Results</title><p>The minor allele frequencies (MAFs) of two single nucleotide polymorphisms (SNPs) were not significantly different among the five regions. The most frequent haplotype was <italic>SLCO1B1*1b</italic> (frequency: 0.654), followed by <italic>*1a</italic> (frequency: 0.217), <italic>*15</italic> (frequency: 0.128), and <italic>*5</italic> (frequency: 0.001). We observed a similar frequency of OATP1B1 transporter phenotypes compared to other populations. 75.85% of the Thai subjects showed normal OATP1B1 activity, 22.5% showed intermediate OATP1B1 activity, and 1.58% showed low OATP1B1 activity.</p></sec><sec><title>Conclusion</title><p>This study reported the frequencies of the <italic>SLCO1B1</italic> variants and the subsequent OATP1B1 activity in a large cohort of Thais that can provide important information for the guidance of personalized drug therapy.</p></sec>