AUTHOR=Afroz Mohasana , Akter Sanzida , Ahmed Asif , Rouf Razina , Shilpi Jamil A. , Tiralongo Evelin , Sarker Satyajit D. , Göransson Ulf , Uddin Shaikh Jamal TITLE=Ethnobotany and Antimicrobial Peptides From Plants of the Solanaceae Family: An Update and Future Prospects JOURNAL=Frontiers in Pharmacology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00565 DOI=10.3389/fphar.2020.00565 ISSN=1663-9812 ABSTRACT=
The Solanaceae is an important plant family that has been playing an essential role in traditional medicine and human nutrition. Members of the Solanaceae are rich in bioactive metabolites and have been used by different tribes around the world for ages. Antimicrobial peptides (AMPs) from plants have drawn great interest in recent years and raised new hope for developing new antimicrobial agents for meeting the challenges of antibiotic resistance. This review aims to summarize the reported AMPs from plants of the Solanaceae with possible molecular mechanisms of action as well as to correlate their traditional uses with reported antimicrobial actions of the peptides. A systematic literature study was conducted using different databases until August 2019 based on the inclusion and exclusion criteria. According to literature, a variety of AMPs including defensins, protease inhibitor, lectins, thionin-like peptides, vicilin-like peptides, and snaking were isolated from plants of the Solanaceae and were involved in their defense mechanism. These peptides exhibited significant antibacterial, antifungal and antiviral activity against organisms for both plant and human host.