AUTHOR=Tan Shengnan , Hua Xin , Xue Zheyong , Ma Jianzhang 

TITLE=Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00473

DOI=10.3389/fphar.2020.00473

ISSN=1663-9812

ABSTRACT=<p>Antimicrobial resistance has become a serious threat to human and animal health, and vancomycin-resistant <italic>Enterococcus</italic> has become an important nosocomial infection pathogen, causing thousands of deaths each year. In this study, after screening a variety of natural products, we found that cajanin stilbene acid (CSA) had significant inhibitory effect on sensitive and vancomycin-resistant <italic>Enterococcus</italic> (VRE) <italic>in vitro</italic>. And we also confirmed that CSA had significant anti-VRE infection ability <italic>in vivo</italic>. Subsequently, we studied the antibacterial mechanism of CSA through proteomics experiments, and the results showed that CSA killed <italic>Enterococcus</italic> by inhibiting the phosphotransferase system of <italic>Enterococcus</italic>, thus hinders the normal growth and metabolic functions of bacteria. The results of this study provided evidence for the in-depth study on the mechanism of the antibacterial action of CSA and also provided a candidate for the development of anti-VRE drugs.</p>