AUTHOR=Toro Mario D. , Nowakowska Dominika , Brzozowska Agnieszka , Reibaldi Michele , Avitabile Teresio , Bucolo Claudio , Murabito Paolo , Chisari Clara , Nowomiejska Katarzyna , Rejdak Robert 

TITLE=Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00440

DOI=10.3389/fphar.2020.00440

ISSN=1663-9812

ABSTRACT=<sec><title>Purpose</title><p>To assess the pain intensity of two intracameral anesthetic solutions in patients undergoing cataract surgery and evaluate the factors influencing the patients’ postoperative activities.</p></sec><sec><title>Methods</title><p>Sixty-two patients undergoing cataract surgery were randomized to receive the study drug – a manufactured solution of 0.02% tropicamide/0.31% phenylephrine/1% lidocaine (Mydrane) or a traditional anesthetic formulation - solution of 1% lidocaine/0.025% adrenaline as an intraocular anesthetic. The pain intensity was assessed by Visual Analog Scale for Pain (VAS Pain) and Brief Pain Inventory-short form (BPI) on the next day after the surgery.</p></sec><sec><title>Results</title><p>The mean pain score measured preoperatively with VAS Pain was 0.34 in Mydrane group and 0.09 in the reference group (<italic>p</italic> = 0.51). There were no statistically significant differences between the two anesthetic methods with respect to pain intensity during the surgery (<italic>p</italic> = 0.94) and the influence of pain during the last 24 h on activity (<italic>p</italic> = 0.79), mood (<italic>p</italic> = 0.31), social contacts (<italic>p</italic> = 0.29), sleep (<italic>p</italic> = 0.5) and the joy of life (<italic>p</italic> = 0.39). Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases (<italic>p</italic> = 0.98) and post-operative complications (<italic>p</italic> = 0.4) on the experienced pain measured during the surgery and in the last 24 h.</p></sec><sec><title>Conclusions</title><p>New commercially available intraocular anesthetic solution (Mydrane™) seems to be as effective as off-label traditional anesthetic formulation, in reducing the pain experienced during cataract surgery under topical anesthesia.</p></sec>