AUTHOR=Horváth Balázs , Hézső Tamás , Kiss Dénes , Kistamás Kornél , Magyar János , Nánási Péter P. , Bányász Tamás 

TITLE=Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents

JOURNAL=Frontiers in Pharmacology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00413

DOI=10.3389/fphar.2020.00413

ISSN=1663-9812

ABSTRACT=<p>Based on recent findings, an increased late sodium current (I<sub>Na,late</sub>) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is I<sub>Na,late</sub> and how it functions under physiological circumstances. Next, it shows the wide range of cellular mechanisms that can contribute to an increased I<sub>Na,late</sub> in heart diseases, and also discusses how the upregulated I<sub>Na,late</sub> can play a role in the generation of cardiac arrhythmias. The last part of the article is about I<sub>Na,late</sub> inhibiting drugs as potential antiarrhythmic agents, based on experimental and preclinical data as well as in the light of clinical trials.</p>